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Recruitment for doctoral studies in Maj Insitute of Pharmacology has started!  Research topics – IF PAN – KISD (ifj.edu.pl)   If you are interested in issues related to drug-resistant depression - join our team!
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Special Issue "Depression, Anxiety, and Post Traumatic Stress Disorder (PTSD) in Women"

Dear Colleagues, According to the World Health Organization, severe depression is expected to become the leading cause of morbidity around the world by 2030. The development of the COVID-19 pandemic is certain to contribute to many disorders, from post-traumatic stress disorders and anxiety to depression. All studies to date indicate that women are more than twice as likely to develop depression. In addition, being a woman increases the likelihood of anxiety disorders by 85%. Neurohormones, which are often activated under stress, can also have a significant impact on the development of these conditions. Chronic stress consequently leads to the dysregulation of neurohormones, which can lead to the development of depression and anxiety. It therefore seems important to draw attention to the involvement of neurohormones in the development of mood disorders, especially since women's hormonal system changes many times during their lives. Therefore, I invite and encourage all authors who ...
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Time-course of changes in key catecholaminergic receptors and trophic systems in rat brain after antidepressant administration

Time is needed to observe the effects of antidepressants.  A large study by Chiodo and Antelman, using an electrophysiological approach, showed a hypersensitivity of dopamine D2 autoreceptors 7-10 days after a single dose of imipramine or after electroshock, with an effect identical to that observed after chronic administration of pharmacological or non-pharmacological stimuli (Chiodo and Antelman, 1980). Based on large behavioural and biochemical data, a theory of 'time-dependent sensitisation' was proposed. Antelman postulated that dosage represents a foreign stress stimulus and, like activation of the immune system, can induce changes that are not immediate but can be long-lasting. According to Antelman, tissues exposed to a drug for the first time recognise its foreign nature and activate rapid non-specific adaptive processes, such as amphetamine-induced corticosterone release, which can also be observed two weeks after a single amphetamine dose (Antelman et al., 1992). How...
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